SNP Variants in Major Histocompatibility Complex Are Associated with Sarcoidosis Susceptibility—A Joint Analysis in Four European Populations

SNP Variants in Major Histocompatibility Complex Are Associated with Sarcoidosis Susceptibility—A Joint Analysis in Four European Populations

Sarcoidosis is a multiorgan inflammatory disorder with heritability estimates up to 66%. Previous studies have shown the major histocompatibility complex (MHC) region to be associated with sarcoidosis, suggesting a functional role for antigen-presenting molecules and immune mediators in the disease...

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Main Authors: Elisa Laura Lahtela, Annika Wolin, Verneri Anttila, Martin Petrek, Johan Grunewald, Coline H. M. van Moorsel, Anders Eklund, Jan C. Grutters, Vitezslav Kolek, Frantisek Mrazek, Amit Kishore, Leonid Padyukov, Anne Pietinalho, Marcus Ronninger, Mikko Seppänen, Olof Selroos, Marja-Liisa Lokki
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
BTNL2
SNP
DRB1
HLA
prognosis
sarcoidosis
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00422/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00422/full

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