Rolipram plays an anti-fibrotic effect in ligamentum flavum fibroblasts by inhibiting the activation of ERK1/2

Rolipram plays an anti-fibrotic effect in ligamentum flavum fibroblasts by inhibiting the activation of ERK1/2

Abstract Background Fibrosis is an important factor and process of ligamentum flavum hypertrophy. The expression of phosphodiesterase family (PDE) is related to inflammation and fibrosis. This article studied the expression of PDE in hypertrophic ligamentum flavum fibroblasts and investigated whethe...

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Bibliographic Details
Main Authors: Likang Wu, Lei Xu, Yu Chen, Guohua Xu, Qunfeng Guo, Depeng Meng, Jianping Fan, Guoqiang Song, Peng Xu
Format: Article
Language:English
Published: BMC 2021-09-01
Series:BMC Musculoskeletal Disorders
Subjects:
Rolipram
Phosphodiesterase
Ligamentum Flavum hypertrophy
ERK1/2
Fibrosis
TGF-β1
Online Access:https://doi.org/10.1186/s12891-021-04712-9

Internet

https://doi.org/10.1186/s12891-021-04712-9

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