The Helminth Parasite Heligmosomoides polygyrus Attenuates EAE in an IL-4Rα-Dependent Manner

The Helminth Parasite Heligmosomoides polygyrus Attenuates EAE in an IL-4Rα-Dependent Manner

Helminth parasites are effective in biasing Th2 immunity and inducing regulatory pathways that minimize excessive inflammation within their hosts, thus allowing chronic infection to occur whilst also suppressing bystander atopic or autoimmune diseases. Multiple sclerosis (MS) is a severe autoimmune...

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Bibliographic Details
Main Authors: Madeleine P. J. White, Chris J. C. Johnston, John R. Grainger, Joanne E. Konkel, Richard A. O'Connor, Stephen M. Anderton, Rick M. Maizels
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
intestinal nematode
multiple sclerosis (MS)
Th2 (type-2) immune responses
cytokine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01830/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.01830/full

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