IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway

IGFBPrP1 accelerates autophagy and activation of hepatic stellate cells via mutual regulation between H19 and PI3K/AKT/mTOR pathway

Background: Our previous study found that insulin-like growth factor binding protein-associated protein (IGFBPrP1) drives hepatic stellate cells (HSCs) activation, and IGFBPrP1 and transforming growth factor β1 (TGFβ1) likely interact with each other to promote HSCs activation. TGFβ1 reportedly prom...

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Bibliographic Details
Main Authors: Ting-Juan Huang, Jun-Jie Ren, Qian-Qian Zhang, Yang-Yang Kong, Hai-Yan Zhang, Xiao-Hong Guo, Hui-Qin Fan, Li-Xin Liu
Format: Article
Language:English
Published: Elsevier 2019-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Autophagy
Hepatic stellate cells
Hepatic fibrosis
Insulin-like growth factor binding protein-related protein 1
PI3K/AKT/mTOR
LncRNA H19
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219309746

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http://www.sciencedirect.com/science/article/pii/S0753332219309746

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