Low-dose thioperamide injected into the cerebellar vermis of mice immediately after exposure to the elevated plus-maze impairs their avoidance behavior on re-exposure to the apparatus

Low-dose thioperamide injected into the cerebellar vermis of mice immediately after exposure to the elevated plus-maze impairs their avoidance behavior on re-exposure to the apparatus

The present study investigated the effect of thioperamide (THIO), an H3 histaminergic receptor antagonist, microinjected into the cerebellar vermis on emotional memory consolidation in male Swiss albino mice re-exposed to the elevated plus-maze (EPM). We implanted a guide cannula into the cerebellar...

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Bibliographic Details
Main Authors: J. Costa Neto, K.R. Serafim, A.C.L. Gianlorenco, R. Mattioli
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2013-11-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Histaminergic system
Cerebellum
H3
Emotional memory
Memory consolidation
Elevated plus-maze
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100943&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013001100943&lng=en&tlng=en

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