Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries

Glioblastoma is a severe type of brain tumor with a poor prognosis and few therapy options. Temozolomide (TMZ) is one of these options, however, with limited success, and failure is mainly due to tumor resistance. In this work, genome-wide CRISPR-Cas9 lentiviral screen libraries for gene knockout or...

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Bibliographic Details
Main Authors: Clarissa Ribeiro Reily Rocha, Alexandre Reily Rocha, Matheus Molina Silva, Luciana Rodrigues Gomes, Marcela Teatin Latancia, Marina Andrade Tomaz, Izadora de Souza, Linda Karolynne Seregni Monteiro, Carlos Frederico Martins Menck
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:Cells
Subjects:
temozolomide
cancer resistance
glioblastoma
CRISPR library
NRF2
Online Access:https://www.mdpi.com/2073-4409/9/12/2573

Internet

https://www.mdpi.com/2073-4409/9/12/2573

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