Gli2 and gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function.
Intraflagellar transport (IFT) proteins are essential for cilia assembly and have recently been associated with a number of developmental processes, such as left-right axis specification and limb and neural tube patterning. Genetic studies indicate that IFT proteins are required for Sonic hedgehog (...
| Format: | Article |
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| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-10-01
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| Series: | PLoS Genetics |
| Online Access: | http://dx.doi.org/10.1371/journal.pgen.0010053 |