Phosphoproteomic Landscaping Identifies Non-canonical cKIT Signaling in Polycythemia Vera Erythroid Progenitors

Phosphoproteomic Landscaping Identifies Non-canonical cKIT Signaling in Polycythemia Vera Erythroid Progenitors

Although stem cell factor (SCF)/cKIT interaction plays key functions in erythropoiesis, cKIT signaling in human erythroid cells is still poorly defined. To provide new insights into cKIT-mediated erythroid expansion in development and disease, we performed phosphoproteomic profiling of primary eryth...

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Bibliographic Details
Main Authors: Giulia Federici, Lilian Varricchio, Fabrizio Martelli, Mario Falchi, Orietta Picconi, Federica Francescangeli, Paola Contavalli, Gabriella Girelli, Agostino Tafuri, Emanuel F. Petricoin, Maria Mazzarini, Ann Zeuner, Anna Rita Migliaccio
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Oncology
Subjects:
stem cell factor
cKIT
erythropoiesis
polycythemia vera
erythroid progenitors
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2019.01245/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2019.01245/full

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