Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

Caspase-mediated cleavage of IRE1 controls apoptotic cell commitment during endoplasmic reticulum stress

Upon detecting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive cellular changes to reestablish homeostasis. If stress resolution fails, the UPR commits the cell to apoptotic death. Here we show that in hematopoietic cells, including multiple myeloma (MM),...

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Bibliographic Details
Main Authors: Anna Shemorry, Jonathan M Harnoss, Ofer Guttman, Scot A Marsters, László G Kőműves, David A Lawrence, Avi Ashkenazi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-08-01
Series:eLife
Subjects:
apoptosis
BAX
XBP1
cancer
hematopoietic
myeloma
Online Access:https://elifesciences.org/articles/47084

Internet

https://elifesciences.org/articles/47084

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