Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.

Decline of FoxP3+ Regulatory CD4 T Cells in Peripheral Blood of Children Heavily Exposed to Malaria.

FoxP3+ regulatory CD4 T cells (Tregs) help to maintain the delicate balance between pathogen-specific immunity and immune-mediated pathology. Prior studies suggest that Tregs are induced by P. falciparum both in vivo and in vitro; however, the factors influencing Treg homeostasis during acute and ch...

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Bibliographic Details
Main Authors: Michelle J Boyle, Prasanna Jagannathan, Lila A Farrington, Ijeoma Eccles-James, Samuel Wamala, Tara I McIntyre, Hilary M Vance, Katherine Bowen, Felistas Nankya, Ann Auma, Mayimuna Nalubega, Esther Sikyomu, Kate Naluwu, John Rek, Agaba Katureebe, Victor Bigira, James Kapisi, Jordan Tappero, Mary K Muhindo, Bryan Greenhouse, Emmanuel Arinaitwe, Grant Dorsey, Moses R Kamya, Margaret E Feeney
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-07-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4504515?pdf=render

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http://europepmc.org/articles/PMC4504515?pdf=render

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