Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes

Natural and pathogenic protein sequence variation affecting prion-like domains within and across human proteomes

Abstract Background Impaired proteostatic regulation of proteins with prion-like domains (PrLDs) is associated with a variety of human diseases including neurodegenerative disorders, myopathies, and certain forms of cancer. For many of these disorders, current models suggest a prion-like molecular m...

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Bibliographic Details
Main Authors: Sean M. Cascarina, Eric D. Ross
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Genomics
Subjects:
Prion-like domains
Sequence variation
Protein aggregation
Prion
Prion prediction
Neurodegenerative disease
Online Access:https://doi.org/10.1186/s12864-019-6425-3

Internet

https://doi.org/10.1186/s12864-019-6425-3

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