EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization

EZH2 promotes DNA replication by stabilizing interaction of POLδ and PCNA via methylation-mediated PCNA trimerization

Abstract Background Proliferating cell nuclear antigen (PCNA), a ring-shaped homotrimer complex, promotes DNA replication via binding to DNA polymerase. Trimerized PCNA is critical for DNA replication. Enhancer of zeste homologue 2 (EZH2), which primarily acts as a histone methyltransferase, is esse...

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Bibliographic Details
Main Authors: Peng A, Xinyi Xu, Chenglin Wang, Jing Yang, Shida Wang, Jiewen Dai, Ling Ye
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Epigenetics & Chromatin
Subjects:
EZH2
PCNA
DNA replication
Methylation
Online Access:http://link.springer.com/article/10.1186/s13072-018-0213-1

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http://link.springer.com/article/10.1186/s13072-018-0213-1

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