Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

Abstract Background The complicated cellular and biochemical changes that occur in brain during Alzheimer’s disease are poorly understood. In a previous study we used an unbiased label-free quantitative mass spectrometry-based proteomic approach to analyze these changes at a systems level in post-mo...

Full description

Bibliographic Details
Main Authors: Erik C. B. Johnson, Eric B. Dammer, Duc M. Duong, Luming Yin, Madhav Thambisetty, Juan C. Troncoso, James J. Lah, Allan I. Levey, Nicholas T. Seyfried
Format: Article
Language:English
Published: BMC 2018-10-01
Series:Molecular Neurodegeneration
Subjects:
Alzheimer’s disease
Proteomics
Proteogenomics
RNA binding protein
RNA splicing
Online Access:http://link.springer.com/article/10.1186/s13024-018-0282-4

Internet

http://link.springer.com/article/10.1186/s13024-018-0282-4

Similar Items