Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.

Altered hematopoiesis in mice lacking DNA polymerase mu is due to inefficient double-strand break repair.

Polymerase micro (Polmicro) is an error-prone, DNA-directed DNA polymerase that participates in non-homologous end-joining (NHEJ) repair. In vivo, Polmicro deficiency results in impaired Vkappa-Jkappa recombination and altered somatic hypermutation and centroblast development. In Polmicro(-/-) mice,...

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Bibliographic Details
Main Authors: Daniel Lucas, Beatriz Escudero, José Manuel Ligos, Jose Carlos Segovia, Juan Camilo Estrada, Gloria Terrados, Luis Blanco, Enrique Samper, Antonio Bernad
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-02-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2638008?pdf=render

Internet

http://europepmc.org/articles/PMC2638008?pdf=render

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