Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.

Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.

Eicosanoids are bioactive lipid mediators derived from arachidonic acid(1) (AA), which is released by cytosolic phospholipase A2 (cPLA2). AA is metabolized through three major pathways, cyclooxygenase (COX), lipoxygenase (LO) and cytochrome P450, to produce a family of eicosanoids, which individuall...

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Bibliographic Details
Main Authors: Joanna M Poczobutt, Miguel Gijon, Jay Amin, Dwight Hanson, Howard Li, Deandra Walker, Mary Weiser-Evans, Xian Lu, Robert C Murphy, Raphael A Nemenoff
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3823604?pdf=render

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http://europepmc.org/articles/PMC3823604?pdf=render

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