Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1.

Extra-epitopic hepatitis C virus polymorphisms confer resistance to broadly neutralizing antibodies by modulating binding to scavenger receptor B1.

Broadly-neutralizing monoclonal antibodies (bNAbs) may guide vaccine development for highly variable viruses including hepatitis C virus (HCV), since they target conserved viral epitopes that could serve as vaccine antigens. However, HCV resistance to bNAbs could reduce the efficacy of a vaccine. HC...

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Bibliographic Details
Main Authors: Ramy El-Diwany, Valerie J Cohen, Madeleine C Mankowski, Lisa N Wasilewski, Jillian K Brady, Anna E Snider, William O Osburn, Ben Murrell, Stuart C Ray, Justin R Bailey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-02-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5342271?pdf=render

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http://europepmc.org/articles/PMC5342271?pdf=render

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