Implementation and implications for polygenic risk scores in healthcare

Implementation and implications for polygenic risk scores in healthcare

Abstract Increasing amounts of genetic data have led to the development of polygenic risk scores (PRSs) for a variety of diseases. These scores, built from the summary statistics of genome-wide association studies (GWASs), are able to stratify individuals based on their genetic risk of developing va...

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Bibliographic Details
Main Authors: John L. Slunecka, Matthijs D. van der Zee, Jeffrey J. Beck, Brandon N. Johnson, Casey T. Finnicum, René Pool, Jouke-Jan Hottenga, Eco J. C. de Geus, Erik A. Ehli
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Human Genomics
Subjects:
Polygenic risk score
PRS
Clinical genetics
Genetic risk
Risk stratification
Public health
Online Access:https://doi.org/10.1186/s40246-021-00339-y

Internet

https://doi.org/10.1186/s40246-021-00339-y

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