Trimethylamine N-Oxide Exacerbates Renal Inflammation and Fibrosis in Rats With Diabetic Kidney Disease

Trimethylamine N-Oxide Exacerbates Renal Inflammation and Fibrosis in Rats With Diabetic Kidney Disease

The gut microbiota plays a pivotal role in the onset and development of diabetes and its complications. Trimethylamine N-oxide (TMAO), a gut microbiota-dependent metabolite of certain nutrients, is associated with type 2 diabetes and its complications. Diabetic kidney disease (DKD) is one of the mos...

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Bibliographic Details
Main Authors: Qing Fang, Binjie Zheng, Na Liu, Jinfeng Liu, Wenhui Liu, Xinyi Huang, Xiangchang Zeng, Lulu Chen, Zhenyu Li, Dongsheng Ouyang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Physiology
Subjects:
trimethylamine N-oxide
diabetic kidney disease
inflammation
NLRP3
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.682482/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.682482/full

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