A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

Overproduced yeast ribosomal protein (RP) Rpl26 fails to assemble into ribosomes and is degraded in the nucleus/nucleolus by a ubiquitin-proteasome system quality control pathway comprising the E2 enzymes Ubc4/Ubc5 and the ubiquitin ligase Tom1. tom1 cells show reduced ubiquitination of multiple RPs...

Full description

Bibliographic Details
Main Authors: Min-Kyung Sung, Tanya R Porras-Yakushi, Justin M Reitsma, Ferdinand M Huber, Michael J Sweredoski, André Hoelz, Sonja Hess, Raymond J Deshaies
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-08-01
Series:eLife
Subjects:
protein quality control
ribosomal protein
ubiquitin-proteasome system
Online Access:https://elifesciences.org/articles/19105

Internet

https://elifesciences.org/articles/19105

Similar Items