Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families

Tumor sequencing is useful to refine the analysis of germline variants in unexplained high-risk breast cancer families

Abstract Background Multigene panels are routinely used to assess for predisposing germline mutations in families at high breast cancer risk. The number of variants of unknown significance thereby identified increases with the number of sequenced genes. We aimed to determine whether tumor sequencing...

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Bibliographic Details
Main Authors: Cédric Van Marcke, Raphaël Helaers, Anne De Leener, Ahmad Merhi, Céline A. Schoonjans, Jérôme Ambroise, Christine Galant, Paul Delrée, Françoise Rothé, Isabelle Bar, Elsa Khoury, Pascal Brouillard, Jean-Luc Canon, Peter Vuylsteke, Jean-Pascal Machiels, Martine Berlière, Nisha Limaye, Miikka Vikkula, François P. Duhoux
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Breast Cancer Research
Subjects:
Breast cancer
Predisposition
Germline
Second hit
Variant of unknown significance
Mutational signatures
Online Access:http://link.springer.com/article/10.1186/s13058-020-01273-y

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http://link.springer.com/article/10.1186/s13058-020-01273-y

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