Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis

Complement components are upregulated and correlate with disease progression in the TDP-43Q331K mouse model of amyotrophic lateral sclerosis

Abstract Background Components of the innate immune complement system have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS) specifically using hSOD1 transgenic animals; however, a comprehensive examination of complement expression in other transgenic ALS models has not been...

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Bibliographic Details
Main Authors: John D. Lee, Samantha C. Levin, Emily F. Willis, Rui Li, Trent M. Woodruff, Peter G. Noakes
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Neuroinflammation
Online Access:http://link.springer.com/article/10.1186/s12974-018-1217-2

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http://link.springer.com/article/10.1186/s12974-018-1217-2

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