The Inhibitory Action of Kohamaic Acid A Derivatives on Mammalian DNA Polymerase β

The Inhibitory Action of Kohamaic Acid A Derivatives on Mammalian DNA Polymerase β

We previously isolated a novel natural product, designated kohamaic acid A (KA-A, compound 1), as an inhibitor of the first cleavage of fertilized sea urchin eggs, and found that this compound could selectively inhibit the activities of mammalian DNA polymerases (pols). In this paper, we investigate...

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Bibliographic Details
Main Authors: Yoshiyuki Mizushina, Daisuke Manita, Toshifumi Takeuchi, Yuko Kumamoto-Yonezawa, Yuki Matsui, Fumio Sugawara, Masaharu Takemura, Hirosato Takikawa, Hiromi Yoshida, Mitsuru Sasaki
Format: Article
Language:English
Published: MDPI AG 2008-12-01
Series:Molecules
Subjects:
Kohamaic acid A (KA-A)
DNA polymerase (DNA-directed DNA polymerase [E.C. 2.7.7.7]
pol)
Enzyme inhibitor
Cytotoxicity
Computer simulation
Online Access:http://www.mdpi.com/1420-3049/14/1/102/

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http://www.mdpi.com/1420-3049/14/1/102/

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