Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity

Diurnal expression of MRP4 in bone marrow cells underlies the dosing-time dependent changes in the oxaliplatin-induced myelotoxicity

Abstract The expression and function of some xenobiotic transporters varies according to the time of day, causing the dosing time-dependent changes in drug disposition and toxicity. Multidrug resistance-associated protein-4 (MRP4), an ATP­binding cassette (ABC) efflux transporter encoded by the Abcc...

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Bibliographic Details
Main Authors: Mizuki Kato, Yuya Tsurudome, Takumi Kanemitsu, Sai Yasukochi, Yuki Kanado, Takashi Ogino, Naoya Matsunaga, Satoru Koyanagi, Shigehiro Ohdo
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-70321-6

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https://doi.org/10.1038/s41598-020-70321-6

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