Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children

Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children

Obesity is often accompanied by metabolic and haemodynamic disorders such as hypertension, even during childhood. Arachidonic acid (AA) is metabolized by cytochrome P450 (CYP450) enzymes to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE), vasoactive and natriuretic met...

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Bibliographic Details
Main Authors: Sara Bonafini, Alice Giontella, Angela Tagetti, Denise Marcon, Martina Montagnana, Marco Benati, Rossella Gaudino, Paolo Cavarzere, Mirjam Karber, Michael Rothe, Pietro Minuz, Franco Antoniazzi, Claudio Maffeis, Wolf Hagen Schunck, Cristiano Fava
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:Nutrients
Subjects:
CYP450 eicosanoids
omega-3 PUFA
omega-6 PUFA
blood pressure
hemodynamics
children
EETs
EEQs
Online Access:https://www.mdpi.com/2072-6643/10/11/1689

Internet

https://www.mdpi.com/2072-6643/10/11/1689

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