Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives

Synthesis and In Vitro Antiproliferative Activity of Novel Androst-5-ene Triazolyl and Tetrazolyl Derivatives

A straightforward and reliable method for the regioselective synthesis of steroidal 1,4-disubstituted triazoles and 1,5-disubstituted tetrazoles via copper(I)-catalyzed cycloadditions is reported. Heterocycle moieties were efficiently introduced onto the starting azide compound 3β-acetoxy-16β-azidom...

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Bibliographic Details
Main Authors: János Wölfling, Tibor Bartók, Éva Frank, Gyula Schneider, Judit Huber, István Zupkó, Dóra Kovács, Zalán Kádár
Format: Article
Language:English
Published: MDPI AG 2011-06-01
Series:Molecules
Subjects:
click chemistry
steroid azides
triazoles
tetrazoles
CuAAC
Online Access:http://www.mdpi.com/1420-3049/16/6/4786/

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