Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol

Regio and stereoselective synthesis of anticancer spirooxindolopyrrolidine embedded piperidone heterocyclic hybrids derived from one-pot cascade protocol

Abstract Background Spiropyrrolidine tethered piperidone heterocyclic hybrids were synthesized with complete regio- and stereoselectively in excellent yield via a tandem three-component 1,3-dipolar cycloaddition and subsequent enamine reaction in [bmim]Br. The synthesized compounds were evaluated fo...

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Bibliographic Details
Main Authors: Natarajan Arumugam, Abdulrahman I. Almansour, Raju Suresh Kumar, Dhaifallah M. Al-thamili, Govindasami Periyasami, V. S. Periasamy, Jegan Athinarayanan, Ali A. Alshatwi, S. M. Mahalingam, J. Carlos Menéndez
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Chemistry Central Journal
Subjects:
Spiropyrrolidine
Piperidone
Domino reactions
Chemo divergent multicomponent reactions
Antiproliferative activity
Apoptosis induction
Online Access:http://link.springer.com/article/10.1186/s13065-018-0462-x

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http://link.springer.com/article/10.1186/s13065-018-0462-x

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