Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

Neuraminidase is the main target for current influenza drugs. Reduced susceptibility to oseltamivir, the most widely prescribed neuraminidase inhibitor, has been repeatedly reported. The resistance substitutions I223V and S247N, alone or in combination with the major oseltamivir-resistance mutation...

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Bibliographic Details
Main Authors: Jana Pokorná, Petr Pachl, Elena Karlukova, Jakub Hejdánek, Pavlína Řezáčová, Aleš Machara, Jason Hudlický, Jan Konvalinka, Milan Kožíšek
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Viruses
Subjects:
influenza neuraminidase
resistance
oseltamivir
isothermal titration calorimetry
crystal structure
Online Access:http://www.mdpi.com/1999-4915/10/7/339

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http://www.mdpi.com/1999-4915/10/7/339

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