Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits

Partial loss in septo-hippocampal cholinergic neurons alters memory-dependent measures of brain connectivity without overt memory deficits

The functional relevance of septo-hippocampal cholinergic (SHC) degeneration to the degradation of hippocampus-dependent declarative memory (DM) in aging and Alzheimer's disease (AD) remains ill-defined. Specifically, selective SHC lesions often fail to induce overt memory impairments in animal...

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Bibliographic Details
Main Authors: Laurent Brayda-Bruno, Nicole Mons, Benjamin K. Yee, Jacques Micheau, Djoher Nora Abrous, Xavier Nogues, Aline Marighetto
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neurobiology of Disease
Subjects:
Declarative memory
Aging
P75 saporin immunotoxin
Radial arm maze
Fos immunohistochemistry
Functional connectivity
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611300034X

Internet

http://www.sciencedirect.com/science/article/pii/S096999611300034X

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