Case Report: Predicting the Range of Lamotrigine Concentration Using Pharmacokinetic Models Based on Monte Carlo Simulation: A Case Study of Antiepileptic Drug-Related Leukopenia

Case Report: Predicting the Range of Lamotrigine Concentration Using Pharmacokinetic Models Based on Monte Carlo Simulation: A Case Study of Antiepileptic Drug-Related Leukopenia

Lamotrigine (LTG), a wide-spectrum antiepileptic drug, is frequently associated with cutaneous side-effects, whereas hematological side-effects such as leukopenia have rarely been reported for it. We report the case of a 15-year-old Chinese female epileptic patient weighing 60 kg who developed combi...

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Bibliographic Details
Main Authors: Xiuqing Zhu, Tao Xiao, Shanqing Huang, Shujing Liu, Xiaolin Li, Dewei Shang, Yuguan Wen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Pharmacology
Subjects:
lamotrigine
pharmacokinetic models
Monte Carlo simulation
case report
adolescence
steady-state serum concentrations
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.706329/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.706329/full

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