Nesfatin-1 Suppresses Cardiac L-type Ca2+ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway

Nesfatin-1 Suppresses Cardiac L-type Ca2+ Channels Through Melanocortin Type 4 Receptor and the Novel Protein Kinase C Theta Isoform Pathway

Background/Aims: Nesfatin-1 (NF-1), an anorexic nucleobindin-2 (NUCB2)-derived hypothalamic peptide, acts as a peripheral cardiac modulator and it can induce negative inotropic effects. However, the mechanisms underlying these effects in cardiomyocytes remain unclear. Methods: Using patch clamp, pro...

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Bibliographic Details
Main Authors: Jiaoqian Ying, Yuan Zhang, Shan Gong, Zhigang Chang, Xiaofeng Zhou, Hua Li, Jin Tao, Guoqiang Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Nesfatin-1
L-type Ca2+ channels
Protein kinase C
Cardiomyocytes
Online Access:http://www.karger.com/Article/FullText/430120

Internet

http://www.karger.com/Article/FullText/430120

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