OPCML is hypermethylated in a subset of patients with metaplastic changes in their esophagus

OPCML is hypermethylated in a subset of patients with metaplastic changes in their esophagus

Abstract OPCML hypermethylation is considered a promising cancer biomarker. We examined methylation levels in the first exon of OPCML in two patient cohorts within the esophageal adenocarcinoma and gastric adenocarcinoma cascades and in a range of cell-lines using a custom PyroMark CpG assay. Methyl...

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Bibliographic Details
Main Authors: Natalia Castaño-Rodríguez, Georgia L. Popple, Gloria Liliana Porras-Hurtado, José Luis Cardona-Deazza, Juan José Montoya-Martinez, Antonio Javier Cadavid-Velez, Héctor William Toro-Hidalgo, Alba Ruth Cobo-Alvarado, Ofelia del Socorro Hincapié-Rincón, Stephen M. Riordan, Nadeem O. Kaakoush
Format: Article
Language:English
Published: BMC 2018-12-01
Series:Biomarker Research
Subjects:
OPCML
CpG methylation
Dysplasia
Adenocarcinoma
Online Access:http://link.springer.com/article/10.1186/s40364-018-0150-y

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http://link.springer.com/article/10.1186/s40364-018-0150-y

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