FH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through Tankyrases

FH535 Suppresses Osteosarcoma Growth In Vitro and Inhibits Wnt Signaling through Tankyrases

Osteosarcoma (OS) is an aggressive primary bone tumor which exhibits aberrantly activated Wnt signaling. The canonical Wnt signaling cascade has been shown to drive cancer progression and metastasis through the activation of β-catenin. Hence, small molecule inhibitors of Wnt targets are being explor...

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Bibliographic Details
Main Authors: Carl T. Gustafson, Tewodros Mamo, Kristen L. Shogren, Avudaiappan Maran, Michael J. Yaszemski
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-05-01
Series:Frontiers in Pharmacology
Subjects:
osteosarcoma
tankyrase inhibitor
PARP1
Wnt signaling
small molecule chemotherapy
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00285/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2017.00285/full

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