AMPK activation by ASP4132 inhibits non-small cell lung cancer cell growth

Abstract Activation of adenosine monophosphate-activated protein kinase (AMPK) is able to produce significant anti-non-small cell lung cancer (NSCLC) cell activity. ASP4132 is an orally active and highly effective AMPK activator. The current study tested its activity against NSCLC cells. In primary...

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Bibliographic Details
Main Authors: Ying-chen Xia, Jian-hua Zha, Yong-Hua Sang, Hui Yin, Guo-qiu Xu, Jie Zhen, Yan Zhang, Ben-tong Yu
Format: Article
Language:English
Published: Nature Publishing Group 2021-04-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-03655-2