Highly efficient correction of structural mutations of 450 kb KIT locus in kidney cells of Yorkshire pig by CRISPR/Cas9

Highly efficient correction of structural mutations of 450 kb KIT locus in kidney cells of Yorkshire pig by CRISPR/Cas9

Abstract The white coat colour of Yorkshire and Landrace pig breeds is caused by the dominant white I allele of KIT, associated with 450-kb duplications and a splice mutation (G > A) at the first base in intron 17. To test whether genome editing can be employed to correct this structural mutation...

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Bibliographic Details
Main Authors: Ke Qin, Xinyu Liang, Guanjie Sun, Xuan Shi, Min Wang, Hongbo Liu, Yaosheng Chen, Xiaohong Liu, Zuyong He
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Molecular and Cell Biology
Subjects:
CRISPR/Cas9
KIT
Pig
Structural variation
Online Access:http://link.springer.com/article/10.1186/s12860-019-0184-5

Internet

http://link.springer.com/article/10.1186/s12860-019-0184-5

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