Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation

Dexmedetomidine attenuates myocardial ischemia-reperfusion injury in vitro by inhibiting NLRP3 Inflammasome activation

Abstract Background Myocardial ischemia-reperfusion injury (MIRI) is the most common cause of death worldwide. The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome plays an important role in the inflammatory response to MIRI. Dexmedetomidine (DEX), a specific agonist of α2-adren...

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Bibliographic Details
Main Authors: Yaru Huang, Xiaotong Sun, Zhaodong Juan, Rui Zhang, Ruoguo Wang, Shuqi Meng, Jiajia Zhou, Yan Li, Keyou Xu, Keliang Xie
Format: Article
Language:English
Published: BMC 2021-04-01
Series:BMC Anesthesiology
Subjects:
Cardiac fibroblasts
NLRP3 inflammasome
Dexmedetomidine
Hypoxia and reoxygenation injury
Online Access:https://doi.org/10.1186/s12871-021-01334-5

Internet

https://doi.org/10.1186/s12871-021-01334-5

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