Calcium Signaling and Contractility in Cardiac Myocyte of Wolframin Deficient Rats

Calcium Signaling and Contractility in Cardiac Myocyte of Wolframin Deficient Rats

Wolframin (Wfs1) is a membrane protein of the sarco/endoplasmic reticulum. Wfs1 mutations are responsible for the Wolfram syndrome, characterized by diabetic and neurological symptoms. Although Wfs1 is expressed in cardiac muscle, its role in this tissue is not clear. We have characterized the effec...

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Bibliographic Details
Main Authors: Michal Cagalinec, Alexandra Zahradníková, Dominika Kováčová, Ludovit Paulis, Simona Kureková, Matej Hot’ka, Jana Pavelková, Mario Plaas, Marta Novotová, Ivan Zahradník
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Physiology
Subjects:
calcium current
calcium transient
contractility
cardiac myocyte
Wolfram syndrome
wolframin
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00172/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00172/full

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