Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery

Identification of potential binding pocket on viral oncoprotein HPV16 E6: a promising anti-cancer target for small molecule drug discovery

Abstract Background Several human cancers, especially cervical cancer are caused by the infection of high risk strains of human papillomaviruses (HPV), notably HPV16. It is implicated that the oncoprotein E6 expressed from HPV, is inhibiting the apoptotic pathway by binding to adaptor molecule FADD...

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Bibliographic Details
Main Authors: Srikanth Kolluru, Rosemary Momoh, Lydia Lin, Jayapal Reddy Mallareddy, John L. Krstenansky
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Molecular and Cell Biology
Subjects:
Human papilloma virus
HPV E6
Myricetin
Flavonol
Molecular modelling
Online Access:http://link.springer.com/article/10.1186/s12860-019-0214-3

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http://link.springer.com/article/10.1186/s12860-019-0214-3

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