Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C δ pathway

Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a protein kinase C δ pathway

Abnormal HDL metabolism among patients with diabetes and insulin resistance may contribute to their increased risk of atherosclerosis. ABCA1 mediates the transport of cholesterol and phospholipids from cells to HDL apolipoproteins and thus modulates HDL levels and atherogenesis. Unsaturated fatty ac...

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Bibliographic Details
Main Authors: Wang Yutong, John F. Oram
Format: Article
Language:English
Published: Elsevier 2007-05-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter A1
high density lipoproteins
cardiovascular disease
diabetes
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520435527

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http://www.sciencedirect.com/science/article/pii/S0022227520435527

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