Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

Chitosan-capped enzyme-responsive hollow mesoporous silica nanoplatforms for colon-specific drug delivery

Abstract An enzyme-responsive colon-specific delivery system was developed based on hollow mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) was attached via cleavable azo bonds (HMSS–N=N–CS). Doxorubicin (DOX) was encapsulated in a noncrystalline state in the hollow cavity and m...

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Bibliographic Details
Main Authors: Defu Cai, Cuiyan Han, Chang Liu, Xiaoxing Ma, Jiayi Qian, Jianwen Zhou, Yue Li, Yiming Sun, Changting Zhang, Wenquan Zhu
Format: Article
Language:English
Published: SpringerOpen 2020-06-01
Series:Nanoscale Research Letters
Subjects:
Hollow mesoporous silica spheres
Colon specific drug delivery
Enzyme-responsive
Doxorubicin
Online Access:http://link.springer.com/article/10.1186/s11671-020-03351-8

Internet

http://link.springer.com/article/10.1186/s11671-020-03351-8

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