Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway

Herbal formula Huang Qin Ge Gen Tang enhances 5-fluorouracil antitumor activity through modulation of the E2F1/TS pathway

Abstract Background 5-Fluorouracil (5-FU) remains the most widely used agent to treat colorectal cancer (CRC). However, its clinical efficacy is currently limited by the development of drug resistance. Traditional Chinese Herbal Medicine (TCM) has been shown to enhance the efficacy of standard antic...

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Bibliographic Details
Main Authors: Haizhou Liu, Hui Liu, Zhiyi Zhou, Robert A. Parise, Edward Chu, John C. Schmitz
Format: Article
Language:English
Published: BMC 2018-02-01
Series:Cell Communication and Signaling
Subjects:
Colorectal cancer
Thymidylate synthase
5-fluorouracil
Traditional Chinese herbal medicine
Online Access:http://link.springer.com/article/10.1186/s12964-018-0218-1

Internet

http://link.springer.com/article/10.1186/s12964-018-0218-1

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