Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

Modulation of let-7 miRNAs controls the differentiation of effector CD8 T cells

The differentiation of naive CD8 T cells into effector cytotoxic T lymphocytes upon antigen stimulation is necessary for successful antiviral, and antitumor immune responses. Here, using a mouse model, we describe a dual role for the let-7 microRNAs in the regulation of CD8 T cell responses, where m...

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Bibliographic Details
Main Authors: Alexandria C Wells, Keith A Daniels, Constance C Angelou, Eric Fagerberg, Amy S Burnside, Michele Markstein, Dominique Alfandari, Raymond M Welsh, Elena L Pobezinskaya, Leonid A Pobezinsky
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-07-01
Series:eLife
Subjects:
CTL
naive CD8 T cells
TCR
Eomes
Myc
metabolism
Online Access:https://elifesciences.org/articles/26398

Internet

https://elifesciences.org/articles/26398

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