Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells

Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells

Type 2 diabetes mellitus (T2DM) has been associated with insulin resistance and the failure of β-cells to produce and secrete enough insulin as the disease progresses. However, clinical treatments based solely on insulin secretion and action have had limited success. The focus is therefore shifting...

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Bibliographic Details
Main Authors: Vladimir Grubelnik, Rene Markovič, Saška Lipovšek, Gerd Leitinger, Marko Gosak, Jurij Dolenšek, Ismael Valladolid-Acebes, Per-Olof Berggren, Andraž Stožer, Matjaž Perc, Marko Marhl
Format: Article
Language:English
Published: The Royal Society 2020-01-01
Series:Royal Society Open Science
Subjects:
diabetes
pancreatic α-cell
glucagon
mitochondrial dysfunction
free fatty acid
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.191171

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https://royalsocietypublishing.org/doi/pdf/10.1098/rsos.191171

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