Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics

Assessment of genetic integrity, splenic phagocytosis and cell death potential of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid and its effect when combined with commercial chemotherapeutics

Abstract The increased incidence of cancer and its high treatment costs have encouraged the search for new compounds to be used in adjuvant therapies for this disease. This study discloses the synthesis of (Z)-4-((1,5-dimethyl-3-oxo-2-phenyl-2,3dihydro-1H-pyrazol-4-yl) amino)-4-oxobut-2-enoic acid (...

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Bibliographic Details
Main Authors: Rodrigo Juliano Oliveira, Naiara da Cruz Leite Santos, João Renato Pesarini, Beatriz Carneiro de Oliveira, Claudia Rodrigues Berno, Flávio Henrique Souza de Araújo, Ingridhy Ostaciana Maia Freitas da Silveira, Raquel Oliveira Nascimento, Andréia Conceição Milan Brochado Antoniolli-Silva, Antônio Carlos Duenhas Monreal, Adilson Beatriz, Dênis Pires de Lima, Roberto da Silva Gomes
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2018-02-01
Series:Genetics and Molecular Biology
Subjects:
Splenic phagocytosis
comet assay
micronucleus test
cell death
chemoprevention
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005002102&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572018005002102&lng=en&tlng=en

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