Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

Oct4 promotes M2 macrophage polarization through upregulation of macrophage colony-stimulating factor in lung cancer

Abstract Background Expression of Oct4 maintains cancer stem cell (CSC)-like properties in lung cancer cells and is correlated with poor prognosis of lung adenocarcinoma. M2-type tumor-associated macrophages (TAMs) promote cancer cell migration and metastasis. Tumor microenvironments promote monocyt...

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Bibliographic Details
Main Authors: Chia-Sing Lu, Ai-Li Shiau, Bing-Hua Su, Tsui-Shan Hsu, Chung-Teng Wang, Yu-Chu Su, Ming-Shian Tsai, Yin-Hsun Feng, Yau-Lin Tseng, Yi-Ting Yen, Chao-Liang Wu, Gia-Shing Shieh
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Journal of Hematology & Oncology
Subjects:
Lung cancer
Oct4
M2 macrophage
Tumor-associated macrophage
M-CSF
Online Access:http://link.springer.com/article/10.1186/s13045-020-00887-1

Internet

http://link.springer.com/article/10.1186/s13045-020-00887-1

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