HMEJ-mediated site-specific integration of a myostatin inhibitor increases skeletal muscle mass in porcine

HMEJ-mediated site-specific integration of a myostatin inhibitor increases skeletal muscle mass in porcine

As a robust antagonist of myostatin (MSTN), follistatin (FST) is an important regulator of skeletal muscle development, and the delivery of FST to muscle tissue represents a potential therapeutic strategy for muscular dystrophies. The N terminus and FSI domain of FST are the functional domains for M...

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Bibliographic Details
Main Authors: Mengjing Li, Xiaochun Tang, Wenni You, Yanbing Wang, Yiwu Chen, Ying Liu, Hongming Yuan, Chuang Gao, Xue Chen, Zhiwei Xiao, Hongsheng Ouyang, Daxin Pang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
pig
FST
MSTN
CRISPR-Cas9
HMEJ
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001529

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http://www.sciencedirect.com/science/article/pii/S2162253121001529

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