Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

Dynamic 13C Flux Analysis Captures the Reorganization of Adipocyte Glucose Metabolism in Response to Insulin

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Summary: Cellular metabolism is dynamic, but quantifying non-steady metabolic fluxes by stable isotope tracers presents unique computational challenges. Here, we developed an efficient 13C-tracer dynamic metabolic flux analysis (13C-DMFA) framework for modeling central carbon fluxes that vary over t...

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Bibliographic Details
Main Authors: Lake-Ee Quek, James R. Krycer, Satoshi Ohno, Katsuyuki Yugi, Daniel J. Fazakerley, Richard Scalzo, Sarah D. Elkington, Ziwei Dai, Akiyoshi Hirayama, Satsuki Ikeda, Futaba Shoji, Kumi Suzuki, Jason W. Locasale, Tomoyoshi Soga, David E. James, Shinya Kuroda
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220300389

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http://www.sciencedirect.com/science/article/pii/S2589004220300389

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