Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: a possible association between survival rate and ITPA polymorphism.

Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: a possible association between survival rate and ITPA polymorphism.

Genetic polymorphisms are important factors in the effects and toxicity of chemotherapeutics. To analyze the pharmacogenetic and ethnic differences in chemotherapeutics, major genes implicated in the treatment of acute lymphoblastic leukemia (ALL) were analyzed. Eighteen loci of 16 genes in 100 pati...

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Main Authors: Hyery Kim, Hyoung Jin Kang, Hyo Jeong Kim, Mi Kyung Jang, Nam Hee Kim, Yongtaek Oh, Byoung-Don Han, Ji-Yeob Choi, Chul Woo Kim, Ji Won Lee, Kyung Duk Park, Hee Young Shin, Hyo Seop Ahn
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3454425?pdf=render

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http://europepmc.org/articles/PMC3454425?pdf=render

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