Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains

Analysis of α-Dystroglycan/LG Domain Binding Modes: Investigating Protein Motifs That Regulate the Affinity of Isolated LG Domains

Dystroglycan (DG) is an adhesion complex that links the cytoskeleton to the surrounding extracellular matrix in skeletal muscle and a wide variety of other tissues. It is composed of a highly glycosylated extracellular α-DG associated noncovalently with a transmembrane β-DG whose cytodomain interact...

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Bibliographic Details
Main Authors: Christopher E. Dempsey, Maria Giulia Bigotti, Josephine C. Adams, Andrea Brancaccio
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Molecular Biosciences
Subjects:
dystroglycan
laminin globular (LG) domains
binding affinities
protein modeling
protein structure
Online Access:https://www.frontiersin.org/article/10.3389/fmolb.2019.00018/full

Internet

https://www.frontiersin.org/article/10.3389/fmolb.2019.00018/full

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