Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

Combination of Oncolytic Herpes Simplex Viruses Armed with Angiostatin and IL-12 Enhances Antitumor Efficacy in Human Glioblastoma Models

Oncolytic herpes simplex virus (oHSV) can potentially spread throughout the tumor, reach isolated infiltrating cells, kill them, and deliver anticancer agents. However, the host responds to oHSV by inducing intratumoral infiltration of macrophages that can engulf the virus, limiting the potential o...

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Bibliographic Details
Main Authors: Wei Zhang, Giulia Fulci, Hiroaki Wakimoto, Tooba A. Cheema, Jason S. Buhrman, Deva S. Jeyaretna, Anat O. Stemmer Rachamimov, Samuel D. Rabkin, Robert L. Martuza
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613801327

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http://www.sciencedirect.com/science/article/pii/S1476558613801327

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