Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase

Design, synthesis, molecular docking, and in vitro α-glucosidase inhibitory activities of novel 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines against yeast and rat α-glucosidase

Abstract In an attempt to find novel, potent α-glucosidase inhibitors, a library of poly-substituted 3-amino-2,4-diarylbenzo[4,5]imidazo[1,2-a]pyrimidines 3a–ag have been synthesized through heating a mixture of 2-aminobenzimidazoles 1 and α-azidochalcone 2 under the mild conditions. This efficient,...

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Bibliographic Details
Main Authors: Fariba Peytam, Ghazaleh Takalloobanafshi, Toktam Saadattalab, Maryam Norouzbahari, Zahra Emamgholipour, Setareh Moghimi, Loghman Firoozpour, Hamid Reza Bijanzadeh, Mohammad Ali Faramarzi, Somayeh Mojtabavi, Parviz Rashidi-Ranjbar, Saeed Karima, Roya Pakraad, Alireza Foroumadi
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-91473-z

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https://doi.org/10.1038/s41598-021-91473-z

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